Karolina Drążkowska, PhD

Postdoc

(+48) 22 592 2027, (+48) 22 592 2024
Room no. 034, 028

Involved in: Research on RNA metabolism

Projekt Lider: Nowe enzymy do analiz RNA w skali całego  transkryptomu i ich wykorzystanie do badania molekularnego mechanizmu antynowotworowego działania 5-fluorouracylu.

 

Academic and Research Career:

Institute of Genetics and Biotechnology, University of Warsaw and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, since April 2013
Postdoc, Laboratory of RNA Biology and Functional Genomics, advised by Andrzej Dziembowski

Institute of Genetics and Biotechnology, University of Warsaw and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, October 2008 – April 2013
PhD Student, research group led by Andrzej Dziembowski, advised by Andrzej Dziembowski and Rafał Tomecki

Institute of Genetics and Biotechnology, University of Warsaw, 2007 – 2008
Master Student, research group led by Andrzej Dziembowski, advised by Andrzej Dziembowski

Institute of Genetics and Biotechnology, University of Warsaw, 2007
Bachelor Student, research group led by Andrzej Dziembowski, advised by Andrzej Dziembowski

Publications:

hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0.
Tomecki R, Labno A, Drazkowska K, Cysewski D, Dziembowski A.
RNA Biol. 2015;12(9):1010-29.

Purification of eukaryotic exoribonucleases following heterologous expression in bacteria and analysis of their biochemical properties by in vitro enzymatic assays. 
Tomecki R, Drazkowska K, Krawczyk A, Kowalska K, Dziembowski A.
Methods Mol Biol. 2015;1259:417-52.

Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target.
Tomecki R, Drazkowska K, Kucinski I, Stodus K, Szczesny RJ, Gruchota J, Owczarek EP, Kalisiak K, Dziembowski A.
Nucleic Acids Res. 2013 Oct 22. [Epub ahead of print]

The RNA exosome complex central channel controls both exonuclease and endonuclease Dis3 activities in vivo and in vitro.
Drazkowska K, Tomecki R, Stodus K, Kowalska K, Czarnocki-Cieciura M, Dziembowski A.
Nucleic Acids Res. 2013 Apr 1;41(6):3845-58. Epub 2013 Feb 12.

RNA channelling by the eukaryotic exosome.
Malet H, Topf M, Clare DK, Ebert J, Bonneau F, Basquin J, Drazkowska K, Tomecki R, Dziembowski A, Conti E, Saibil HR, Lorentzen E.
EMBO Rep. 2010 Dec;11(12):936-42. Epub 2010 Nov 12.

The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L.
Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen KM, Szczesny RJ, Drazkowska K, Pastula A, Andersen JS, Stepien PP, Dziembowski A, Jensen TH.
EMBO J. 2010 Jul 21;29(14):2342-57. Epub 2010 Jun 8.

Mechanisms of RNA degradation by the eukaryotic exosome.
Tomecki R, Drazkowska K, Dziembowski A.
Chembiochem. 2010 May 3;11(7):938-45.

Awards:

START programme Stipend for Young Scientists from the Foundation for Polish Science (2014)

Award of the Rector of the University of Warsaw for the best PhD thesis (2013)

Team award of the Rector of the University of Warsaw for scientific achievements (2011)

Award of the IBB PAS Research Council for the best original publication in the year 2010 (2011)

Scholarship for the best doctoral students and young PhDs (The Modern University – a comprehensive support programme for doctoral students and teaching staff of the University of Warsaw) (2010/2011)

Fellowship from the Foundation for Polish Science within the TEAM Programme (2009-2013)