Zbigniew Warkocki, PhD
Postdoc
(+48) 22 592 2024
Room no. 028, 034
Current position:
Head of Department of RNA Metabolism, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland
Involved in: Molecular biology and biochemistry of RNA and RNA-protein ensembles
Academic and Research Career:
Institute of Biochemistry and Biophysics Polish Academy of Sciences (Warsaw, PL), 2012-2018
Postdoc, Laboratory of RNA Biology and Functional Genomics, advised by Andrzej Dziembowski
Max-Planck-Institute for Biophysical Chemistry (Goettingen, DE), 2007-2012
PhD student and postdoc, Department of Cellular Biochemistry, advised by Reinhard Luehrmann
Albrecht-von-Haller-Institute (Goettingen, DE), 2007
Trainee, Department of Plant Biochemistry, advised by Martin Fulda
Institute for Bioorganic Chemistry (Poznan, PL), 2005-2007
MSc student, Laboratory of Molecular Biology of Plants, advised by Marek Figlerowicz
Adam-Mickiewicz-University (Poznan, PL), 2005
BSc student, Department of Gene Expression, advised by Artur Jarmolowski
Publications:
Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.
Warkocki Z, Krawczyk PS, Adamska D, Bijata K, Garcia-Perez JL, Dziembowski A.
Cell. 2018 Sep 6;174(6):1537-1548.e29. doi: 10.1016/j.cell.2018.07.022.
Versatile approach for functional analysis of human proteins and efficient stable cell line generation using FLP-mediated recombination system.
Szczesny RJ, Kowalska K, Klosowska-Kosicka K, Chlebowski A, Owczarek EP, Warkocki Z, Kulinski TM, Adamska D, Affek K, Jedroszkowiak A, Kotrys AV, Tomecki R, Krawczyk PS, Borowski LS, Dziembowski A.
PLoS One. 2018 Mar 28;13(3):e0194887. doi: 10.1371/journal.pone.0194887. eCollection 2018.
Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components.
Razew M, Warkocki Z, Taube M, Kolondra A, Czarnocki-Cieciura M, Nowak E, Labedzka-Dmoch K, Kawinska A, Piatkowski J, Golik P, Kozak M, Dziembowski A, Nowotny M.
Nat Commun. 2018 Jan 8;9(1):97. doi: 10.1038/s41467-017-02570-5.
Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs.
Łabno A, Warkocki Z, Kuliński T, Krawczyk PS, Bijata K, Tomecki R, Dziembowski A.
Nucleic Acids Res. 2016 Jul 18. pii: gkw649.
The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome.
Warkocki Z, Schneider C, Mozaffari-Jovin S, Schmitzová J, Höbartner C, Fabrizio P, Lührmann R.
Genes Dev. 2015 Jan 1;29(1):94-107. doi: 10.1101/gad.253070.114.
Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system.
Ohrt T, Odenwälder P, Dannenberg J, Prior M, Warkocki Z, Schmitzová J, Karaduman R, Gregor I, Enderlein J, Fabrizio P, Lührmann R.
RNA. 2013 Jul;19(7):902-15. doi: 10.1261/rna.039024.113
Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components.
Warkocki Z, Odenwälder P, Schmitzová J, Platzmann F, Stark H, Urlaub H, Ficner R, Fabrizio P, Lührmann R.
Nat Struct Mol Biol. 2009 Dec;16(12):1237-43. doi: 10.1038/nsmb.1729.
[Trans-acting short interfering RNAs].
Warkocki Z, Figlerowicz M.
Postepy Biochem. 2006;52(3):253-9. Review. Polish.
Leadered Grants:
FUGA grant of the National Science Center (Narodowe Centrum Nauki) – 2012-2015
Selected Awards:
START Scholarship of the Foundation for Polish Science (Fundacja na Rzecz Nauki Polskiej) for outstanding young scientists 2014/2015
Kekule Scholarship of the Foundation of the German Chemical Industry (Fonds der chemischen Industrie) – 2008-2010
Scholarship of the Polish Ministry of Education for outstanding examination grades and scientific achievements – 2006/2007