Monika Kusio-Kobiałka, PhD

Postdoc

(+48) 22 592 2034
Room no. 034

 

Involved in: molecular cell biology, flow cytometry 

Academic and Research Career:

Laboratory of RNA Biology and Functional Genomics, Institute of Biochemistry and Biophysics, PAS, since 2016, postdoc

Laboratory of Molecular and Cellular Signalling, Centre of New Technologies, University of Warsaw, 2015-2016, postdoc

Department of Oncology, Central Hospital of Vaud University, 2013-2014, postdoc

Labolatory of Flow Cytometry & Molecular Bases of Aging, Nencki Institute of Experimental Biology, PAS, 2007-2013, PhD student

Laboratory of Bacterial Physiology, Univeristy of Warsaw, 2002-2007, BSc and MSc Student

Publications:

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.
Coni S, Mancuso AB, Di Magno L, Sdruscia G, Manni S, Serrao SM, Rotili D, Spiombi E, Bufalieri F, Petroni M, Kusio-Kobialka M, De Smaele E, Ferretti E, Capalbo C, Mai A, Niewiadomski P, Screpanti I, Di Marcotullio L, Canettieri G.
Sci Rep. 2017 Mar 9;7:44079. doi: 10.1038/srep44079

Nonclassical monocyte mediate the depletion of tumor-infiltrating Tregs via ipilimumab-dependent ADCC in melanoma patients.
Romano E., Kusio-Kobiałka M., Foukas P.G., Baumgaeter P., Meyer C., Ballabeni P., Michielin O., Wende B., Romero P., Speiser D.E.
Proc Natl Acad Sci. Epub ahead of print April 27, 2015, doi:10.1073/pnas.1417320112

Pro-survival signaling pathways activated by BCR-ABL oncogene in chronic myelogenous leukemia cells: the role of the PERK-eIF2α signaling pathway and acetylation of p53.
Kusio-Kobiałka M.
Postepy Biochem. 2014; 60(4): 402-6.

Downregulation of BRCA1 protein In BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation.
Podszywalow-Bartnicka P., Wolczyk M., Kusio-Kobiałka M., Wolanin K., Skowronek K., Nieborowska-Skorska M., Dasgupta Y., Skorski T., Piwocka K.
Cell Cycle. 2014; 13(23):3727-41. doi: 10.4161/15384101.2014.965013.

The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes.
Alster O., Bieleak-Zmijewska A., Mosieniak G., Moreno-Villanueva M., Dudka-Ruszkowska W., Wojtala A., Kusio-Kobiałka M., Korwek Z., Burkle A., Piwocka K., Siwicki J.K., Sikora E.
PLOS ONE. 2014 Aug 13; 9(8):e104964. doi: 10.1371/journal.pone.0104964;

Inhibition of histone acetyltransferase PCAF by anacardic acid derivative leads to apoptosis and breaking resistance to DNA damage In BCR-ABL-expressing cells.
Kusio-Kobiałka M., Dudka-Ruszkowska W., Ghizzoni M., Dekker F.J., Piwocka K.
Anticancer Agents Med Chem. 2013 Jun; 13(5):762-7;

The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signalling and confers resistance to imatinib treatment ich chronic myeloid leukaemia cells.
Kusio-Kobiałka M., Podszywalow-Bartnicka P., Peidis P., Glodkowska-Mrowka E., Wolanin K., Leszak G., Seferynska I., Stoklosa T., Koromilas A., Piwocka K.
Cell Cycle. 2012 Nov 1; 11(21):4069-78. doi: 10.4161/cc.22387. Epub 2012 Oct 24;

Increased acetylation of lysine 317/320 of p53 and mitochondria-dependent apoptosis in response to DNA damage.
Kusio-Kobiałka M., Wolanin K., Podszywalow-Bartnicka P., Sikora E., Skowronek K., McKenna S.L., Ghizzoni M., Dekker F.J., Piwocka K.
Apoptosis. 2012 Sep; 17(9): 950-63. doi: 10.1007/s10495-012-0739-9;

BCR-ABL hits mitosis; Implications for Chromosomal Instability, Aneuploidy and Therapeutic Strategy.
Piwocka K., Wolanin K., Kusio-Kobiałka M., Podszywalow-Bartnicka P.
Wyd. InTech. Myleoid Leukemia – Basic Mechanisms of Leukemogenesis, ISBN 978-953-789-5. 2011; pp:1-26;

Expression of oncogenic kinase Bcr-Abl impairs mitotic checkpoint and promotes aberrant divisions and resistance to microtubule-targeting agents.
Wolanin K., Magalska A., Kusio-Kobiałka M., Podszywalow-Bartnicka P., Vejda S., McKenna S.L., Mosieniak G., Sikora E., Piwocka K.
Mol Cancer Ther. 2010 May; 9(5): 1328-38. doi: 10.1158/1535-7163.MCT-09-09362010;

Inactivation of the wall-associated de-N acetylase (PgdA) of Listeria monocytogenes results in greater suspectibility of the cells to induced autolysis.
Popowska M., Kusio M., Szymanska P., Markiewicz Z.
J Microbiol Biotechnol. 2009 Sep; 19(9):932-45.